Brain is the most fascinating subject for people, second to the universe. Understanding brain has been a passion, with the generosity of youth and their families with severe mood disorders and ADHD, and of course the grand masters that taught me. The work in our field as a whole led the scientists to figure out how the thinking parts of the brain and the feeling parts of the brain interface, and are not working well among those with both the mood disorders and the ADHD relative to healthy peers. What struck me is how even in healthy youth, emotionally charged experiences impact, though not necessarily derail, thinking due to the interface in the underlying brain circuitry. Brains quantitatively as well as qualitatively differ between those who are healthy and those who are ill. Scientists can now look into the brain through the imaging studies that serve as a window to the brain’s structure, function, the integrity of the cable connections between various brain regions.